Strongly dependent on dose, set, and setting, and difficult to predict. At low doses mostly stimulating, euphoric. At high doses, visual illusions and hallucinations. Distortions of body image, speech difficulties and strong mood swings from euphoria to anxiety possible.

Smoked: Average dose at approximately 20-50 mg as free base. The threshold for a high dose is about 0.5-0.7 mg/kg body weight.

Oral: DMT is broken down so quickly by MAO enzymes that it does not produce a hallucinogenic effect on its own. Ayahuasca contains herbal MAO inhibitors in addition to DMT and has a much longer effect than smoked DMT (several hours, depending on ingredients). Usual dosage: 0.6-0.85 mg/kg.

Injections: i.m.: 0.2-1 mg/kg of DMT salt (i.v.: 0.1 to 0.4 mg/kg).

⫸ SIDE EFFECTS

Physical: Dilated pupils, increased heart rate/blood pressure/body temperature, breathing fluctuations, tremors. With ayahuasca consumption often nausea, vomiting, diarrhea.

Psychological: Anxiety & visual distortions possible. 

⫸ TOLERANCE

In contrast to other psychedelics, hardly any development of tolerance after DMT use. No cross-tolerance to LSD, mescaline & psilocybin.

⫸ PARTICULARLY RISK

Especially in persons with histories of psychosis or bipolar disorder. Mixed use with MAO inhibitors.

Use DMT only when you feel psychologically well. Test a small amount and wait at least 90 min. before re-dosing.

Consume only in safe places and with people you trust. Provide a sober companion who can provide assistance in an emergency. Exercise caution when moving and consuming food & beverages.

Vaping can be significantly less harmful than smoking. Use only vaporizers and base liquids from a specialist retailer. 

Injections must be dosed much lower. Always use your own clean injecting equipment.

In case of oral consumption with MAO-inhibitors (Ayahuasca etc.) no consumption of tyramine-containing food, e.g. red wine & certain meat/cheese products, otherwise life-threatening high blood pressure is possible. Check the list online!